Detection of C-Reactive Protein by Liquid-Gated Carbon Nanotube Field Effect Transistors (LG-CNTFET): A Promising Tool against Antibiotic Resistance
نویسندگان
چکیده
Respiratory tract infections have the highest rates of antibiotic prescriptions where symptoms like fever, cough, and rigors are regularly misinterpreted bacterial cannot be distinguished from viral ones. Nevertheless, it has been recently suggested that C-reactive protein (CRP), a produced by liver in response to infection, could serve as potential biomarker for precise differentiation these two types infections. Thus, its quick accurate detection would potentially reduce unnecessary use. To this end, we present an easy sensitive approach selective (CRP) liquid-gated carbon nanotube field effect transistors (LG-CNTFET). Herein, CNT-networks were deposited between electrodes via controlled dielectrophoretic deposition then functionalized with novel specific antibody polyethylene glycol (PEG) layer order overcome Debye screening. The successful fabrication functionalization confirmed scanning electron microscopy. results showed reproducible down picomolar concentrations PBS buffer without complicated microfluidics. simplicity high sensitivity sensor platform make promising tool differential diagnosis
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ژورنال
عنوان ژورنال: Engineering proceedings
سال: 2021
ISSN: ['2673-4591']
DOI: https://doi.org/10.3390/i3s2021dresden-10114